SCHEMBL668595

SCHEMBL668595

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TYMP P19971 5/20 0.43
PRMT6 Q96LA8 1/20 0.40
PRKAG1 P54619 1/20 0.37
PRKAA1 Q13131 1/20 0.37
PRKAB1 Q9Y478 1/20 0.37
P2RY12 Q9H244 1/20 0.36
ADORA1 P30542 1/20 0.36
GAPDH P04406 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25873876 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL29581997 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL24878603 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL26535891 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL2258922 0.98 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL31588239 0.96 TYMP (0.42) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL17861065 0.95 TYMP (0.42) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL24829612 0.94 TYMP (0.41) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL23668111 0.94 TYMP (0.41) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL21073914 0.94 TYMP (0.41) TYMPPRMT6PRKAG1PRKAA1PRKAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2647713-B1 MODIFIED SINGLE-STRAND POLYNUCLEOTIDE DAIICHI SANKYO CO LTD (JP) 2018-02-21 EP disclosed
US-9885036-B2 Double-stranded polynucleotide DAIICHI SANKYO COMPANY, LIMITED (JP) 2018-02-06 US disclosed
EP-2305805-B1 DOUBLE-STRANDED POLYNUCLEOTIDE DAIICHI SANKYO CO LTD (JP) 2015-11-11 EP disclosed
US-8987226-B2 Modified single-stranded polynucleotides DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-03-24 US disclosed
EP-2647713-A1 MODIFIED SINGLE-STRAND POLYNUCLEOTIDE DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-10-09 EP disclosed
US-20130253038-A1 Modified Single-Stranded Polynucleotide DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-09-26 US disclosed
US-20130018085-A1 iRNA Agents Targeting VEGF ALNYLAM PHARMACEUTICALS, INC. 2013-01-17 US disclosed
US-8293719-B2 iRNA agents targeting VEGF ALNYLAM PHARMACEUTICALS, INC. (US) 2012-10-23 US disclosed
EP-2495323-A1 MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE Daiichi Sankyo Company, Limited (JP) 2012-09-05 EP disclosed
US-20120220649-A1 MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-08-30 US disclosed
US-20120045461-A1 Compositions and Methods for Inducing an Immune Response in a Mammal and Methods of Avoiding an Immune Response to Oligonucleotide Agents Such as Short Interfering RNAs ALNYLAM PHARMACEUTICALS, INC. 2012-02-23 US disclosed
US-20110224282-A1 iRNA Agents Targeting VEGF ALNYLAM PHARMACEUTICALS, INC. 2011-09-15 US disclosed
EP-2365077-A1 iRNA agents targeting VEGF Alnylam Pharmaceuticals, Inc. (US) 2011-09-14 EP disclosed
US-8003619-B2 Method of stimulating an immune response and inhibiting expression of a gene using an oligonucleotide ALNYLAM PHARMACEUTICALS, INC. (US) 2011-08-23 US disclosed
US-20110152353-A1 DOUBLE-STRANDED POLYNUCLEOTIDE DAIICHI SANKYO COMPANY, LIMITED 2011-06-23 US disclosed
US-7947659-B2 iRNA agents targeting VEGF ALNYLAM PHARMACEUTICALS, INC. (US) 2011-05-24 US disclosed
EP-2305805-A1 DOUBLE-STRANDED POLYNUCLEOTIDE Daiichi Sankyo Company, Limited (JP) 2011-04-06 EP disclosed
US-7919473-B2 IRNA agents targeting VEGF ALNYLAM PHARMACEUTICALS, INC. (US) 2011-04-05 US disclosed
US-20060217330-A1 Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs BANK OF AMERICA, N.A. 2006-09-28 US disclosed
US-20060094032-A1 iRNA agents targeting VEGF ALNYLAM PHARMACEUTICALS, INC. 2006-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060094032-A1 iRNA agents targeting VEGF KDR, FLT4, SNRPE TYMP 1464/4885PRMT6 1300/4885PRKAG1 926/4885
US-20120220649-A1 MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE POLM, POLN, PNKP TYMP 15/4885PRMT6 3299/4885PRKAG1 2785/4885
US-20110152353-A1 DOUBLE-STRANDED POLYNUCLEOTIDE NSUN2, TRDMT1, POLRMT TYMP 151/4885PRMT6 574/4885PRKAG1 1384/4885
US-20130018085-A1 iRNA Agents Targeting VEGF KDR, FLT4, SNRPE TYMP 1464/4885PRMT6 1300/4885PRKAG1 926/4885
US-20110224282-A1 iRNA Agents Targeting VEGF KDR, FLT4, SNRPE TYMP 1464/4885PRMT6 1300/4885PRKAG1 926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.