SCHEMBL29581997

SCHEMBL29581997

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TYMP P19971 5/20 0.43
PRMT6 Q96LA8 1/20 0.40
PRKAG1 P54619 1/20 0.37
PRKAA1 Q13131 1/20 0.37
PRKAB1 Q9Y478 1/20 0.37
P2RY12 Q9H244 1/20 0.36
ADORA1 P30542 1/20 0.36
GAPDH P04406 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL668595 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL25873876 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL24878603 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL26535891 1.00 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL2258922 0.98 TYMP (0.43) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL31588239 0.96 TYMP (0.42) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL17861065 0.95 TYMP (0.42) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL24829612 0.94 TYMP (0.41) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL23668111 0.94 TYMP (0.41) TYMPPRMT6PRKAG1PRKAA1PRKAB1
SCHEMBL21073914 0.94 TYMP (0.41) TYMPPRMT6PRKAG1PRKAA1PRKAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250002524-A1 CAP ANALOGS HAVING AN ACYCLIC LINKER TO THE GUANINE DERIVATIVE NUCLEOBASE CureVac SE (DE) 2025-01-02 US disclosed
WO-2024222686-A1 RNAI AGENT FOR INHIBITING EXPRESSION OF LPA AND USE OF RNAI AGENT 上海京新生物医药有限公司 2024-10-31 WO disclosed
US-12043673-B2 Complementary RNA linked bispecific T-cell engaging antibodies CITY OF HOPE (US) 2024-07-23 US disclosed
US-20240092821-A1 SYNTHESIS OF OLIGONUCLEOTIDES AND RELATED COMPOUNDS Janssen Biopharma, Inc. 2024-03-21 US disclosed
CN-115843299-A Synthesis of oligonucleotides and related compounds 詹森生物制药有限公司 2023-03-24 CN disclosed
US-20230092615-A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSING OF METHYLATION-CONTROLLED J-PROTEIN (MCJ) MITOTHERAPEUTIX LLC 2023-03-23 US disclosed
EP-4126894-A1 SYNTHESIS OF OLIGONUCLEOTIDES AND RELATED COMPOUNDS Janssen BioPharma, Inc. (US) 2023-02-08 EP disclosed
EP-4107267-A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF METHYLATION-CONTROLLED J-PROTEIN (MCJ) Mitotherapeutix LLC (US) 2022-12-28 EP disclosed
US-20220175934-A1 MULTIVALENT LIGAND CLUSTERS FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS MITOTHERAPEUTIX LLC 2022-06-09 US disclosed
US-20220119552-A1 COMPLEMENTARY RNA LINKED BISPECIFIC T-CELL ENGAGING ANTIBODIES CITY OF HOPE 2022-04-21 US disclosed
CN-114206389-A Multivalent ligand clusters for targeted delivery of therapeutic agents 有丝分裂疗法有限责任公司 2022-03-18 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220119552-A1 COMPLEMENTARY RNA LINKED BISPECIFIC T-CELL ENGAGING ANTIBODIES MCTS1, CD4, CD2 TYMP 615/4885PRMT6 3730/4885PRKAG1 2868/4885
US-12043673-B2 Complementary RNA linked bispecific T-cell engaging antibodies MCTS1, CD4, CD2 TYMP 615/4885PRMT6 3730/4885PRKAG1 2868/4885
US-20220175934-A1 MULTIVALENT LIGAND CLUSTERS FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS ATIC, PCNA, FOLR1 TYMP 240/4885PRMT6 4102/4885PRKAG1 4084/4885
US-20250002524-A1 CAP ANALOGS HAVING AN ACYCLIC LINKER TO THE GUANINE DERIVATIVE NUCLEOBASE RNMT, RNGTT, TRDMT1 TYMP 97/4885PRMT6 1303/4885PRKAG1 939/4885
US-20230092615-A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSING OF METHYLATION-CONTROLLED J-PROTEIN (MCJ) NSUN2, DNAJB11, DNAJB12 TYMP 1793/4885PRMT6 596/4885PRKAG1 222/4885
US-20240092821-A1 SYNTHESIS OF OLIGONUCLEOTIDES AND RELATED COMPOUNDS RNGTT, DCLRE1B, ADAR TYMP 16/4885PRMT6 2252/4885PRKAG1 2233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.