⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896886 | 1.00 | — | — | |
| SCHEMBL15669276 | 1.00 | — | — | |
| SCHEMBL15974698 | 0.79 | FFAR3 (0.35) | — | |
| SCHEMBL16077445 | 0.79 | — | — | |
| SCHEMBL31323093 | 0.79 | TP53 (0.42) | — | |
| SCHEMBL7309246 | 0.78 | TP53 (0.36) | — | |
| SCHEMBL7263270 | 0.78 | TP53 (0.36) | — | |
| SCHEMBL13873968 | 0.78 | — | — | |
| SCHEMBL9313930 | 0.74 | — | — | |
| SCHEMBL19522869 | 0.74 | TP53 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3114138-B1 | IMPROVED MUTEINS OF CLOTTING FACTOR VIII | PFIZER (US) | 2021-11-17 | — | — | EP | disclosed |
| US-20200392205-A1 | MUTEINS OF CLOTTING FACTOR Vlll | PFIZER (US) | 2020-12-17 | — | — | US | disclosed |
| US-10570189-B2 | Muteins of clotting factor VIII | PFIZER INC. (US) | 2020-02-25 | — | — | US | disclosed |
| US-20150306234-A1 | MUTEINS OF CLOTTING FACTOR Vlll | PFIZER INC. | 2015-10-29 | — | — | US | disclosed |
| US-8618266-B2 | Hasylated polypeptides | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2013-12-31 | — | — | US | disclosed |
| EP-1681303-B1 | HASylated polypeptides, especially HASylated erythropoietin | FRESENIUS KABI DE GMBH (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-8475765-B2 | Hydroxyalkyl starch derivatives | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2013-07-02 | — | — | US | disclosed |
| EP-2143736-B1 | Hydroxyalkyl starch derivatives | FRESENIUS KABI DE GMBH (DE) | 2012-11-07 | — | — | EP | disclosed |
| US-20120046240-A9 | Method of Producing Hydroxyalkyl Starch Derivatives | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
| EP-2316850-A2 | HASylated polypeptides, especially HASylated erythropoietin | Fresenius Kabi Deutschland GmbH (DE) | 2011-05-04 | — | — | EP | disclosed |
| EP-0728144-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | DARWIN DISCOVERY LTD (GB) | 2000-01-19 | — | — | EP | disclosed |
| CN-1046525-C | Compounds containing a fused bicyclic ring and processes therefor | BRISTOL MYERS SQUIBB CO (US) | 1999-11-17 | — | — | CN | disclosed |
| US-5853623-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases | CHIROSCIENCE LIMITED (GB) | 1998-12-29 | — | — | US | disclosed |
| US-5756832-A | REACTING AN ALDHYDE WITH AN ORTHOFORMATE IN THE PRESENCE OF AN ACID CATALYST AND AN ALCOHOL | BRISTOL-MYERS SQUIBB CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5672599-A | DUAL ACTION ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND NEUTRAL ENDOPEPTIDASE INHIBITORS; TREATMENT OF CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5670699-A | Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring | BRISTOL-MYERS SQUIBB CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5627278-A | MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION | BRISTOL-MYERS SQUIBB CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5616775-A | ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE | BRISTOL-MYERS SQUIBB CO. (US) | 1997-04-01 | — | — | US | disclosed |
| US-5508272-A | SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0629627-A2 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-21 | — | — | EP | disclosed |