⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668603 | 0.79 | — | — | |
| SCHEMBL6896886 | 0.79 | — | — | |
| SCHEMBL15669276 | 0.79 | — | — | |
| SCHEMBL21542542 | 0.77 | — | — | |
| SCHEMBL13484521 | 0.77 | — | — | |
| SCHEMBL13286236 | 0.77 | — | — | |
| SCHEMBL10759443 | 0.77 | — | — | |
| SCHEMBL6129980 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL6130000 | 0.73 | TSHR (0.33) | — | |
| SCHEMBL5212996 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067898-B1 | Isothiazole derivatives as GPR120 agonists for the treatment of type II diabetes | JANSSEN PHARMACEUTICA NV (BE) | 2015-06-30 | — | — | US | disclosed |
| US-20140275179-A1 | GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-18 | — | — | US | disclosed |