SCHEMBL7263270

SCHEMBL7263270

CC(=O)S[C@H](C(=O)O)C(C)C

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.36
SLC7A5 Q01650 1/20 0.36
BCAT2 O15382 1/20 0.32
TSHR P16473 2/20 0.32
MEN1 O00255 1/20 0.30
HPGD P15428 1/20 0.30
KMT2A Q03164 1/20 0.30
THPO P40225 1/20 0.30
FFAR3 O14843 1/20 0.30
LCK P06239 1/20 0.30
FYN P06241 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7309246 1.00 TP53 (0.36) TP53SLC7A5BCAT2TSHRMEN1
SCHEMBL15974698 0.86 FFAR3 (0.35) TP53TSHRFFAR3LCKFYN
SCHEMBL8883435 0.85 TP53 (0.33) TP53SLC7A5TSHR
SCHEMBL6896886 0.78
SCHEMBL15669276 0.78
SCHEMBL668603 0.78
SCHEMBL19891782 0.77 EPHX1 (0.38)
SCHEMBL8883842 0.77 ALDH1A1 (0.37) TP53TSHRMEN1HPGDKMT2A
SCHEMBL8692002 0.77 ALDH1A1 (0.37) TP53TSHRMEN1HPGDKMT2A
SCHEMBL7304512 0.77 ALDH1A1 (0.37) TP53TSHRMEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003104200-A1 N-MERCAPTOACYL PHENYALANINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLAXO GROUP LIMITED (GB) 2003-12-18 WO disclosed
CN-1058019-C Cyclic amino acid derivativges NOVARTIS AG (CH) 2000-11-01 CN disclosed
EP-0655461-B1 Cyclic amino acid derivatives having ACE and NEP inhibiting activity NOVARTIS AG (CH) 2000-06-07 EP disclosed
EP-0728144-B1 PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES DARWIN DISCOVERY LTD (GB) 2000-01-19 EP disclosed
US-5853623-A Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases CHIROSCIENCE LIMITED (GB) 1998-12-29 US disclosed
US-5801274-A N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1998-09-01 US disclosed
US-5679671-A ANGIOTENSIN 1-CONVERTING ENZYME INHIBITOR, VASOPRESSIN ANTAGONISM AND ATRIAL NAUTRIURETIC PEPTIDE HYDROLASE INHIBITOR EISAI CO., LTD. (JP) 1997-10-21 US disclosed
US-5668158-A TREATMENT OF CARDIOVASCULAR DISORDERS NOVARTIS CORPORATION (US) 1997-09-16 US disclosed
US-5591891-A PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1997-01-07 US disclosed
EP-0728144-A1 PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES Chiroscience Limited (GB) 1996-08-28 EP disclosed
WO-1995035315-A1 GEM-DISUBSTITUTED AMINO ACID DERIVATIVES CIBA-GEIGY AG (CH) 1995-12-28 WO disclosed
EP-0671172-A1 AMINO ACID DERIVATIVE Eisai Co., Ltd. (JP) 1995-09-13 EP disclosed
CN-1107857-A Cyclic amino acid derivativges CIBA GEIGY AG (CH) 1995-09-06 CN disclosed
US-5432186-A Enzyme inhibitors CIBA-GEIGY CORPORATION (US) 1995-07-11 US disclosed
EP-0655461-A1 Cyclic amino acid derivatives having ACE and NEP inhibiting activity CIBA-GEIGY AG (CH) 1995-05-31 EP disclosed
WO-1995013289-A1 PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES CHIROSCIENCE LIMITED (GB) 1995-05-18 WO disclosed
WO-1994017036-A1 S-LIPOPHILIC ALIPHATIC CARBONYL [N-MERCAPTOACYL-(AMINO ACID OR PEPTIDE)] COMPOUNDS AS ANTIHYPERTENSIVE AGENTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1994-08-04 WO disclosed
EP-0595878-A1 ACYLMERCAPTOALKANOYLDIPEPTIDES, METHODS OF PREPARATION AND THEIR THERAPEUTIC USE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1994-05-11 EP disclosed
WO-1993002099-A1 ACYLMERCAPTOALKANOYLDIPEPTIDES, METHODS OF PREPARATION AND THEIR THERAPEUTIC USE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1993-02-04 WO disclosed
EP-0524553-A1 Acylmercaptoalkanoyldipeptides, methods of preparation and their therapeutic use INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1993-01-27 EP disclosed