⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668603 | 1.00 | — | — | |
| SCHEMBL15669276 | 1.00 | — | — | |
| SCHEMBL15974698 | 0.79 | FFAR3 (0.35) | — | |
| SCHEMBL16077445 | 0.79 | — | — | |
| SCHEMBL31323093 | 0.79 | TP53 (0.42) | — | |
| SCHEMBL7309246 | 0.78 | TP53 (0.36) | — | |
| SCHEMBL7263270 | 0.78 | TP53 (0.36) | — | |
| SCHEMBL13873968 | 0.78 | — | — | |
| SCHEMBL9313930 | 0.74 | — | — | |
| SCHEMBL19522869 | 0.74 | TP53 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210299137-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | CYBREXA 1, INC. | 2021-09-30 | — | — | US | disclosed |
| US-10933069-B2 | Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues | CYBREXA 1, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| CN-111989137-A | Compounds, compositions and methods for treating diseases involving acidic or hypoxic diseased tissue | 赛博克萨1公司 | 2020-11-24 | — | — | CN | disclosed |
| EP-3735297-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | Cybrexa 1, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| US-20190209580-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | CYBREXA 1, INC. | 2019-07-11 | — | — | US | disclosed |
| WO-2019136298-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | Cybrexa, Inc. (US) | 2019-07-11 | — | — | WO | disclosed |
| CN-104039356-B | For chitosan targeted delivery and that small molecule integrin antagonist is covalently attached | 弗·哈夫曼-拉罗切有限公司 | 2018-08-17 | — | — | CN | disclosed |
| EP-2750713-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | Spirogen Sàrl (CH) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013055987-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN SÀRL (CH) | 2013-04-18 | — | — | WO | disclosed |
| EP-0629627-B1 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2004-05-06 | — | — | EP | disclosed |
| US-4690937-A | Anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1987-09-01 | — | — | US | disclosed |
| US-4690939-A | Anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1987-09-01 | — | — | US | disclosed |
| US-4689343-A | AGRICULTURE | BAYER AKTIENGESELLSCHAFT (DE) | 1987-08-25 | — | — | US | disclosed |
| US-4684660-A | Mercaptoacyldepeptides | E. R. SQUIBB & SONS, INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4599350-A | PHYTOPATHOGENS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-07-08 | — | — | US | disclosed |
| US-4460601-A | Dipeptides having a methionine residue and possessing a protective action for the liver | MAGGIONI FARMACEUTICI, S.P.A. (IT) | 1984-07-17 | — | — | US | disclosed |
| EP-0009898-B1 | NOVEL ANTI-HYPERTENSIVE MERCAPTOACYLAMINO ACID DERIVATIVES, THEIR PREPARATION AND USE | UNIVERSITY OF MIAMI (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4299842-A | TREATMENT OF RESPIRATORY SYSTEM DISORDERS, NUCOLYTIC AGENTS | CAVAZZA CLAUDIO | 1981-11-10 | — | — | US | disclosed |
| EP-0038117-A1 | Methods for preparing anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0009898-A1 | Novel anti-hypertensive mercaptoacylamino acid derivatives, their preparation and use | UNIVERSITY OF MIAMI (US) | 1980-04-16 | — | — | EP | disclosed |