Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 17/20 | 1.00 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.67 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.67 |
| ▸ | F2 | P00734 | 1/20 | 0.63 |
| ▸ | F10 | P00742 | 1/20 | 0.63 |
| ▸ | F7 | P08709 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921720 | 0.91 | CHEK2 (0.83) | CHEK2PKN1PKN2 | |
| SCHEMBL30832867 | 0.90 | CHEK2 (0.82) | CHEK2PKN1PKN2F2F10 | |
| SCHEMBL20982670 | 0.86 | CHEK2 (0.86) | CHEK2PKN1PKN2 | |
| SCHEMBL5679988 | 0.85 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL179156 | 0.80 | CHEK2 (0.67) | CHEK2F2F10F7 | |
| SCHEMBL29517866 | 0.80 | CHEK2 (0.67) | CHEK2F2F10F7 | |
| SCHEMBL6666180 | 0.80 | CHEK2 (1.00) | CHEK2PKN1PKN2 | |
| SCHEMBL5635897 | 0.80 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL4181904 | 0.79 | METAP2 (0.80) | CHEK2 | |
| SCHEMBL19970726 | 0.79 | F2 (0.70) | CHEK2F2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435947-A1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDS1/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032984-A1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDSI/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | ORTHO-MCNEIL PHARMACEUTICAL,INC. (US) | 2003-04-24 | — | — | WO | disclosed |