Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681744 | 0.80 | LMNA (0.48) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL6171633 | 0.77 | LMNA (0.47) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL6670089 | 0.74 | LMNA (0.47) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL12260750 | 0.71 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL12330285 | 0.71 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL29442794 | 0.68 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL28697223 | 0.68 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL2027987 | 0.68 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL17423729 | 0.68 | LMNA (0.56) | LMNATDP1CYP19A1FFAR4ALDH1A1 | |
| SCHEMBL257945 | 0.68 | LMNA (0.56) | LMNATDP1CYP19A1FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | claimed |