Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681744 | 0.81 | LMNA (0.48) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL6686476 | 0.77 | LMNA (0.48) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL6670089 | 0.73 | LMNA (0.47) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL12330285 | 0.70 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL12260750 | 0.70 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL1900818 | 0.67 | RAB9A (0.39) | LMNATDP1HPGDRAB9AALDH1A1 | |
| SCHEMBL2027987 | 0.67 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL28697223 | 0.67 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL29442794 | 0.67 | LMNA (0.61) | LMNATDP1CYP19A1FFAR4NPC1 | |
| SCHEMBL257945 | 0.67 | LMNA (0.56) | LMNATDP1CYP19A1FFAR4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458385-A4 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-12-21 | — | — | EP | claimed |
| EP-1458385-A2 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-09-22 | — | — | EP | claimed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | claimed |
| WO-2003053922-A2 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2003-07-03 | — | — | WO | claimed |
| EP-1458385-A4 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-12-21 | — | — | EP | disclosed |
| EP-1458385-A2 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053922-A2 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2003-07-03 | — | — | WO | disclosed |