Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | ATP4A | P20648 | 2/20 | 0.44 |
| ▸ | ATP4B | P51164 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564373 | 0.84 | SCN9A (0.62) | SCN9AIKBKBKMOPARP1 | |
| SCHEMBL8119163 | 0.81 | SCN9A (0.55) | SCN9AIKBKBPARP1 | |
| SCHEMBL8123493 | 0.78 | SCN9A (0.51) | SCN9ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8153130 | 0.76 | CA2 (0.55) | SCN9AIKBKBCHUK | |
| SCHEMBL9955528 | 0.76 | CYP19A1 (0.46) | RAB9ANPC1KMOATP4AATP4B | |
| SCHEMBL12170948 | 0.73 | NPC1 (0.66) | IKBKBRAB9ANPC1KMOCNR2 | |
| SCHEMBL10263341 | 0.73 | ENPP3 (0.59) | SCN9ARAB9ANPC1NOTUM | |
| SCHEMBL3821262 | 0.72 | NPC1 (0.59) | IKBKBRAB9ANPC1PARP1NOTUM | |
| SCHEMBL5459832 | 0.72 | SCN9A (1.00) | SCN9A | |
| SCHEMBL14564400 | 0.72 | SCN9A (0.73) | SCN9ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | claimed |