Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | GRK3 | P35626 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688710 | 0.76 | POLB (0.43) | HDAC1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL4797902 | 0.74 | PARP1 (0.41) | PARP1HTR7PARP10PARP14HDAC1 | |
| SCHEMBL18893559 | 0.70 | MEN1 (0.54) | PARP1HTR7PARP10PARP14MEN1 | |
| SCHEMBL19710767 | 0.68 | HTR7 (0.55) | PARP1HTR7PARP10PARP14HDAC8 | |
| SCHEMBL8804295 | 0.67 | PARP1 (0.48) | PARP1HTR7PARP10PARP14HDAC1 | |
| SCHEMBL8294937 | 0.67 | MEN1 (0.57) | PARP1PARP10PARP14MEN1KMT2A | |
| SCHEMBL9448456 | 0.67 | PARP1 (0.51) | PARP1HTR7PARP10PARP14MEN1 | |
| SCHEMBL461708 | 0.67 | HTR7 (0.54) | PARP1HTR7PARP10PARP14HDAC8 | |
| SCHEMBL21555689 | 0.66 | PARP1 (0.48) | PARP1HTR7PARP10PARP14HDAC1 | |
| SCHEMBL6688042 | 0.66 | HTR7 (0.39) | PARP1HTR7PARP10PARP14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |