Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686636 | 0.89 | MAPT (0.42) | TDP1KMT2AMEN1MAPTHTT | |
| SCHEMBL6687560 | 0.86 | MAPT (0.38) | POLBKMT2AMEN1MAPTHTT | |
| SCHEMBL6689081 | 0.81 | TOP2B (0.36) | CA12CA1CA2 | |
| SCHEMBL6687217 | 0.76 | PARP1 (0.42) | HDAC1HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL6688714 | 0.76 | POLB (0.47) | POLBEPHX2TDP1HDAC1HDAC3 | |
| SCHEMBL4798680 | 0.75 | CTSS (0.48) | POLB | |
| SCHEMBL5500899 | 0.69 | EPHX1 (0.52) | POLBHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3021858 | 0.69 | EPHX2 (0.57) | POLBEPHX2KMT2AMEN1MAPT | |
| SCHEMBL9780251 | 0.69 | EPHX2 (0.56) | POLBEPHX2TDP1HDAC1HDAC3 | |
| SCHEMBL6685718 | 0.69 | TDP1 (0.48) | POLBEPHX2TDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |