Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 13/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 1.00 |
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 0.84 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | CTSV | O60911 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465149 | 0.90 | ALDH1A1 (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL6534639 | 0.82 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL29411859 | 0.82 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL2799908 | 0.82 | HPGD (0.76) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL2799465 | 0.82 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL25910937 | 0.81 | ALDH1A1 (0.73) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL15233668 | 0.81 | ALDH1A1 (0.78) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL6534282 | 0.81 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL31552893 | 0.81 | ALDH1A1 (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL22552071 | 0.79 | TUBB4A (0.77) | HPGDALDH1A1KDM4ESMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116497-A1 | Chromane derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2004-06-17 | — | — | US | disclosed |
| EP-1379524-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070515-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2002-09-12 | — | — | WO | disclosed |