Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690654 | 1.00 | CHRNA7 (0.38) | CHRNA7ALDH1A1KDM4EHSD17B10CYP3A4 | |
| SCHEMBL6689152 | 1.00 | CHRNA7 (0.38) | CHRNA7ALDH1A1KDM4EHSD17B10CYP3A4 | |
| SCHEMBL6692758 | 0.81 | SLC6A4 (0.36) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2A6 | |
| SCHEMBL5378828 | 0.79 | SLC6A4 (0.42) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2C19 | |
| SCHEMBL8135115 | 0.78 | FPR2 (0.41) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL2425571 | 0.75 | SMN1; SMN2 (0.46) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL14428530 | 0.72 | CYP3A4 (0.36) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL5383680 | 0.72 | ADORA2B (0.38) | ALDH1A1KDM4EHSD17B10SLC6A2SLC6A4 | |
| SCHEMBL5384192 | 0.72 | ADORA2B (0.38) | ALDH1A1KDM4EHSD17B10SLC6A2SLC6A4 | |
| SCHEMBL5384441 | 0.72 | ADORA2B (0.38) | ALDH1A1KDM4EHSD17B10SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108668-A2 | ALPHA-7 NEURONAL NICOTINIC RECEPTOR LIGANDS: COMPOSITIONS AND METHODS OF USE | TARGACEPT, INC. (US) | 2004-12-16 | — | — | WO | disclosed |
| EP-0994875-A1 | 3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS | R.J. REYNOLDS TOBACCO COMPANY (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999000385-A1 | 3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS | R.J. REYNOLDS TOBACCO COMPANY (US) | 1999-01-07 | — | — | WO | disclosed |