SCHEMBL6692758

SCHEMBL6692758

NCC(c1cccnc1)C1CCOC1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 10/20 0.36
SLC6A2 P23975 9/20 0.36
SLC6A3 Q01959 4/20 0.36
CYP2A6 P11509 2/20 0.36
CYP3A4 P08684 1/20 0.36
CFTR P13569 1/20 0.36
GOPC Q9HD26 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
HSD17B10 Q99714 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
FPR2 P25090 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6690654 0.81 CHRNA7 (0.38) SLC6A4SLC6A2SLC6A3CYP2A6CYP3A4
SCHEMBL6689152 0.81 CHRNA7 (0.38) SLC6A4SLC6A2SLC6A3CYP2A6CYP3A4
SCHEMBL6688396 0.81 CHRNA7 (0.38) SLC6A4SLC6A2SLC6A3CYP2A6CYP3A4
SCHEMBL15797711 0.77 SLC6A4 (0.51) SLC6A4SLC6A2SLC6A3
SCHEMBL5378828 0.76 SLC6A4 (0.42) SLC6A4SLC6A2SLC6A3CYP3A4CFTR
Hydrochloric Acid SCHEMBL15797822 0.76 SLC6A4 (0.50) SLC6A4SLC6A2SLC6A3
SCHEMBL15797675 0.75 KDM4E (0.45) SLC6A4SLC6A2KDM4EALDH1A1MAPT
SCHEMBL8135115 0.73 FPR2 (0.41) CYP3A4SMN1; SMN2HSD17B10KDM4EALDH1A1
SCHEMBL12278622 0.72 TAAR1 (0.42) SMN1; SMN2ALDH1A1
SCHEMBL5383565 0.72 ADORA2B (0.40) SLC6A4SLC6A2SLC6A3CYP2A6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108668-A2 ALPHA-7 NEURONAL NICOTINIC RECEPTOR LIGANDS: COMPOSITIONS AND METHODS OF USE TARGACEPT, INC. (US) 2004-12-16 WO disclosed
EP-0994875-A1 3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 2000-04-26 EP disclosed
WO-1999000385-A1 3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1999-01-07 WO disclosed