Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632064 | 0.77 | FAAH (0.37) | FAAHCTSSXDHCES1NPC1 | |
| SCHEMBL6685143 | 0.68 | CTSS (0.46) | CTSS | |
| SCHEMBL6650333 | 0.68 | CTSS (0.46) | CTSS | |
| SCHEMBL6061887 | 0.68 | CTSS (0.46) | CTSS | |
| SCHEMBL6062621 | 0.68 | CTSS (0.46) | CTSS | |
| SCHEMBL6695509 | 0.66 | FAAH (0.40) | FAAHCTSSXDHCES1MAPT | |
| SCHEMBL6467110 | 0.66 | CTSS (0.44) | FAAHCTSSCES1NPC1RAB9A | |
| SCHEMBL6062624 | 0.66 | FAAH (0.42) | FAAHCTSSCES1LMNASMN1; SMN2 | |
| SCHEMBL6061894 | 0.66 | FAAH (0.42) | FAAHCTSSCES1LMNASMN1; SMN2 | |
| SCHEMBL6651561 | 0.63 | NPC1 (0.33) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |