Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651565 | 0.75 | TSHR (0.38) | NPC1RAB9APOLBPTPN2PTPN1 | |
| SCHEMBL6062924 | 0.68 | REN (0.37) | NPC1RAB9A | |
| SCHEMBL6062927 | 0.68 | REN (0.37) | NPC1RAB9A | |
| SCHEMBL6062920 | 0.68 | REN (0.37) | NPC1RAB9A | |
| SCHEMBL6629735 | 0.66 | FOLH1 (0.37) | NPC1RAB9A | |
| SCHEMBL6696965 | 0.65 | TP53 (0.34) | — | |
| SCHEMBL6687639 | 0.65 | CTSK (0.38) | NPC1RAB9APTPN2PTPN1 | |
| SCHEMBL6685881 | 0.64 | PTPN1 (0.40) | NPC1RAB9APTPN2PTPN1 | |
| SCHEMBL6689303 | 0.63 | FAAH (0.36) | NPC1RAB9A | |
| SCHEMBL6652838 | 0.62 | CTSS (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |