SCHEMBL6689378

SCHEMBL6689378

Nc1cccc(-c2ccc(CO)cc2)c1.OCc1ccc(Br)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 2/20 0.51
CYP3A4 P08684 2/20 0.51
CYP19A1 P11511 2/20 0.51
CYP11B1 P15538 2/20 0.51
CYP11B2 P19099 2/20 0.51
MAOA P21397 1/20 0.50
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.45
MAPT P10636 1/20 0.45
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
KIF11 P52732 1/20 0.41
MAP4K4 O95819 2/20 0.41
MKNK1 Q9BUB5 2/20 0.41
MKNK2 Q9HBH9 2/20 0.41
PRKCI P41743 1/20 0.41
MAPK1 P28482 1/20 0.41
MCL1 Q07820 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3786978 0.91 MAOA (0.59) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL969270 0.86 MAOA (0.67) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL7181909 0.80 MKNK1 (0.47) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL3865773 0.80 ALDH1A1 (0.48) ALDH1A1KDM4EKIF11MKNK1MKNK2
SCHEMBL3785729 0.78 PRKCI (0.58) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL17350172 0.76 CYP3A4 (0.79) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL3787922 0.76 TAAR1 (0.64) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL311194 0.75 MAOA (0.84) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL31131353 0.75 MAOA (0.84) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL29561461 0.75 MAOA (0.84) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1408962-A1 SUBSTITUTED ISOINDOLES AND THE USE THEREOF Bayer HealthCare AG (DE) 2004-04-21 EP disclosed
WO-2003007942-A1 SUBSTITUTED ISOINDOLES AND THE USE THEREOF BAYER HEALTHCARE AG (DE) 2003-01-30 WO disclosed