Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 5/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689531 | 1.00 | ESRRA (0.53) | ESRRAMDM2ERBB2PLK4RET | |
| SCHEMBL6405476 | 0.82 | ERBB2 (0.71) | MDM2ERBB2PLK4DHFREGFR | |
| SCHEMBL6405474 | 0.82 | ERBB2 (0.71) | MDM2ERBB2PLK4DHFREGFR | |
| SCHEMBL5775855 | 0.81 | RAF1 (0.65) | PLK4LRRK2EGFR | |
| SCHEMBL5775852 | 0.81 | RAF1 (0.65) | PLK4LRRK2EGFR | |
| SCHEMBL5472583 | 0.79 | MDM2 (0.63) | MDM2 | |
| SCHEMBL5472587 | 0.79 | MDM2 (0.63) | MDM2 | |
| SCHEMBL6689907 | 0.79 | TUBB4A (0.69) | MDM2RET | |
| SCHEMBL6689901 | 0.79 | TUBB4A (0.69) | MDM2RET | |
| SCHEMBL6405501 | 0.78 | NOX4 (0.64) | ERBB2RETFLT3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069998-A2 | OXINDOLE DERIVATIVES AS ANTIMICROBIAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2004-08-19 | — | — | WO | disclosed |