Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.57 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674338 | 0.87 | L3MBTL1 (0.77) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL22769589 | 0.84 | KMT2A (0.77) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL29482304 | 0.84 | KMT2A (0.77) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL11691275 | 0.84 | ALDH1A1 (1.00) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL25143868 | 0.83 | L3MBTL1 (0.71) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL3844342 | 0.83 | L3MBTL1 (0.71) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL17680501 | 0.83 | L3MBTL1 (0.71) | L3MBTL1ALDH1A1KMT2ANTRK1KDM4E | |
| SCHEMBL11557387 | 0.83 | KMT2A (0.75) | L3MBTL1ALDH1A1KMT2ANTRK1NTRK3 | |
| SCHEMBL4308750 | 0.80 | L3MBTL1 (0.66) | L3MBTL1ALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL7463101 | 0.79 | CCR2 (0.71) | L3MBTL1ALDH1A1KMT2AKDM4EAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054807-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | disclosed |
| EP-1324985-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1324985-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002028831-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-04-11 | — | — | WO | disclosed |
| US-4522808-A | Anti-sunburn compositions containing 2-phenyl-indole derivatives | SOCIETE ANONYME DITE: L'OREAL (FR) | 1985-06-11 | — | — | US | disclosed |
| US-4139634-A | ANTIDEPRESSANTS, ANTIAGGRESSION AGENTS, ANESTHETICS | LABAZ (FR) | 1979-02-13 | — | — | US | disclosed |