Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032867 | 0.86 | HRH3 (0.62) | HRH3DRD3EGFRHRH1 | |
| SCHEMBL7837580 | 0.86 | HRH3 (0.53) | HRH3EGFRTLR9TLR7 | |
| SCHEMBL5680969 | 0.84 | HRH3 (0.55) | HRH3TLR9TLR7 | |
| SCHEMBL30209183 | 0.82 | HRH3 (0.49) | HRH3DRD3EGFRHRH1 | |
| SCHEMBL30979868 | 0.82 | HRH3 (0.54) | HRH3EGFRHRH1 | |
| SCHEMBL3067381 | 0.82 | HRH3 (0.54) | HRH3EGFRHRH1 | |
| SCHEMBL5679317 | 0.82 | HRH3 (0.45) | HRH3DRD3EGFRHRH1HDAC1 | |
| SCHEMBL18128966 | 0.80 | EGFR (0.54) | HRH3DRD3EGFRSLC6A2SLC6A4 | |
| SCHEMBL6390332 | 0.78 | MAOB (0.52) | HRH3EGFRMAOB | |
| SCHEMBL6386440 | 0.76 | KDM4E (0.55) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087120-A2 | USE OF QUINAZOLINE DERIVATIVES WITH SRC KINASE INHIBITORY ACTIVITY FOR THE TREATMENT OF HYPERTENSION | ASTRAZENECA AB (SE) | 2004-10-14 | — | — | WO | disclosed |