SCHEMBL6689699

SCHEMBL6689699

COC1=C(C)C(=O)N2CCN(C(=O)[C@@H](COCc3ccccc3)N(N)C(=O)C(C)C)CC12Cc1ccc(F)cc1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 4/20 0.34
GRM5 P41594 2/20 0.33
UGCG Q16739 2/20 0.32
LMNA P02545 1/20 0.32
CCKBR P32239 1/20 0.31
TACR1 P25103 3/20 0.31
MC4R P32245 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6689702 0.82 GHSR (0.40) GHSRUGCGCCKBRTACR1
SCHEMBL6693779 0.81 GHSR (0.53) GHSRUGCGCCKBR
SCHEMBL6695783 0.81 GHSR (0.53) GHSRUGCGCCKBR
SCHEMBL6689707 0.81 GHSR (0.53) GHSRUGCGCCKBR
SCHEMBL6691999 0.76 GHSR (0.42) GHSRUGCGCCKBRTACR1
SCHEMBL7614494 0.69 GHSR (0.40) GHSRLMNACCKBRTACR1
SCHEMBL6691541 0.67 GHSR (0.54) GHSRUGCGCCKBR
SCHEMBL6691543 0.67 GHSR (0.54) GHSRUGCGCCKBR
SCHEMBL5227924 0.66 GHSR (0.57) GHSRUGCGCCKBR
SCHEMBL6730078 0.66 GHSR (0.38) GHSRGRM5UGCGLMNATACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1002802-B1 Dipeptide derivatives as growth hormone secretagogues PFIZER PROD INC (US) 2004-12-08 EP claimed