Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238040 | 0.79 | NAMPT (0.51) | NAMPTCYP2C9CCR1MAPK8MAPK9 | |
| SCHEMBL6232551 | 0.79 | NAMPT (0.50) | NAMPTCYP2C9MAPK8MAPK9MAPK10 | |
| SCHEMBL6233999 | 0.72 | NAMPT (0.46) | NAMPTCYP2C9CCR1MAPK8MAPK9 | |
| SCHEMBL16088664 | 0.69 | APEX1 (0.74) | CCR1TSHRHSD17B10CYP2C19ALDH1A1 | |
| SCHEMBL933885 | 0.68 | TSHR (0.67) | NAMPTCYP2C9TSHRHSD17B10ALDH1A1 | |
| SCHEMBL933289 | 0.68 | EPHX2 (0.68) | NAMPTCYP2C9TDP1HSD17B10ALDH1A1 | |
| SCHEMBL933464 | 0.67 | ALDH1A1 (0.72) | TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5814687 | 0.67 | KMT2A (0.76) | MAPK8MAPK9MAPK10HSD17B10ALDH1A1 | |
| SCHEMBL1053062 | 0.67 | ALDH1A1 (0.53) | NAMPTCYP2C9CCR1HSD17B10ALDH1A1 | |
| SCHEMBL6266349 | 0.67 | NR1H4 (0.42) | NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434585-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2004-07-07 | — | — | EP | claimed |
| WO-2003032999-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | claimed |