⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201261 | 0.84 | CES2 (0.62) | — | |
| SCHEMBL896787 | 0.84 | CES2 (0.62) | — | |
| SCHEMBL7897291 | 0.82 | — | — | |
| SCHEMBL27770727 | 0.81 | KMT2A (0.60) | — | |
| SCHEMBL30698159 | 0.80 | KMT2A (0.69) | — | |
| SCHEMBL8931340 | 0.80 | — | — | |
| SCHEMBL18639288 | 0.80 | — | — | |
| SCHEMBL13381577 | 0.80 | KMT2A (0.75) | — | |
| SCHEMBL363937 | 0.80 | — | — | |
| SCHEMBL17922016 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109970797-A | Hydroxyformamide derivatives and application thereof | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106103431-B | Hydroxycarboxamide derivatives and their use | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-106103431-A | Hydroxycarboxamide derivatives and their use | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2016-11-09 | — | — | CN | disclosed |
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
| US-5217981-A | Rheumatic diseases, multiple sclerosis, antiinflammatory agent respiratory system disorders, psoriasis | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5179123-A | Furan derivatives; antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-01-12 | — | — | US | disclosed |
| US-5086067-A | Inhibits phospholipase activity which reduces leucotriene production | G. D. SEARLE & CO. (US) | 1992-02-04 | — | — | US | disclosed |