Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230429 | 0.69 | ELANE (0.39) | SIGMAR1HTR2AHTR2CHTR2BELANE | |
| SCHEMBL2870036 | 0.69 | SIGMAR1 (0.36) | SIGMAR1HTR2AHTR2CHTR2BELANE | |
| SCHEMBL5231140 | 0.69 | HTR2C (0.38) | SIGMAR1HTR2AHTR2CHTR2BELANE | |
| SCHEMBL6695304 | 0.69 | HTR2C (0.38) | SIGMAR1HTR2AHTR2CHTR2BELANE | |
| SCHEMBL3861069 | 0.64 | MEN1 (0.43) | SIGMAR1HTR2AHTR2CELANECYP2D6 | |
| SCHEMBL1190778 | 0.63 | KMT2A (0.45) | SIGMAR1HTR2CCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL1191157 | 0.63 | KMT2A (0.45) | SIGMAR1HTR2CCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL28964629 | 0.63 | KMT2A (0.45) | SIGMAR1HTR2CCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL5787980 | 0.63 | LMNA (0.42) | HTR2AHTR2CCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL28308469 | 0.62 | SIGMAR1 (0.44) | SIGMAR1CYP2D6TSHRCYP3A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1002802-B1 | Dipeptide derivatives as growth hormone secretagogues | PFIZER PROD INC (US) | 2004-12-08 | — | — | EP | disclosed |
| US-6194578-B1 | GROWTH HORMONE SECRETAGOGUES; USEFUL FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS AND/OR FRAILTY, INSULIN RESISTANCE IN MAMMALS, CONGESTIVE HEART FAILURE, OBESITY, ACCELERATING BONE FRACTURE REPAIR REDUCING CACHEXIA AND PROTEIN LOSS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1002802-A1 | Dipeptide derivatives as growth hormone secretagogues | Pfizer Products Inc. (US) | 2000-05-24 | — | — | EP | disclosed |