Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216154 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7777242 | 0.80 | PTGS2 (0.80) | PTGS2ADORA3ADORA2AADORA1PTGS1 | |
| SCHEMBL27587265 | 0.79 | PTGS2 (0.68) | PTGS2ADORA3ADORA2AADORA1CSNK1D | |
| SCHEMBL5698543 | 0.74 | PTGS2 (0.72) | PTGS2MAPK14PTGS1 | |
| SCHEMBL3939734 | 0.74 | KMT2A (0.49) | PTGS2ADORA1MEN1KMT2A | |
| SCHEMBL8633781 | 0.73 | PTGS2 (0.67) | PTGS2ADORA3ADORA2AADORA1PTGIR | |
| SCHEMBL8628944 | 0.70 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL1646281 | 0.70 | PTGS2 (0.54) | PTGS2CSNK1DCSNK1EMAPK14MAPK13 | |
| SCHEMBL1645760 | 0.70 | MAPK14 (0.60) | PTGS2ADORA3ADORA2AADORA1CSNK1D | |
| SCHEMBL1647141 | 0.68 | CSNK1D (0.57) | PTGS2CSNK1DCSNK1EMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004096206-A2 | THERAPEUTIC COMBINATION OF A COX-2 INHIBITOR AND A TACE INHIBITOR | PHARMACIA CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |