SCHEMBL669167

SCHEMBL669167

C=Cc1ccc(-c2cccc3ccccc23)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.49
CA1 P00915 3/20 0.49
CA2 P00918 3/20 0.49
CA9 Q16790 3/20 0.49
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
ENPP3 O14638 1/20 0.45
ENPP1 P22413 1/20 0.45
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
CYP1A2 P05177 1/20 0.44
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
ALDH1A1 P00352 2/20 0.43
TSHR P16473 1/20 0.43
PPARG P37231 6/20 0.42
PPARA Q07869 6/20 0.42
PPARD Q03181 1/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5888562 0.91 HPRT1 (0.48) CA12CA1CA2CA9HDAC8
SCHEMBL25569173 0.90 HDAC8 (0.44) CA12CA1CA2CA9HDAC8
SCHEMBL10160455 0.86 CA12 (0.42) CA12CA1CA2CA9HDAC8
SCHEMBL10160453 0.86 CA12 (0.42) CA12CA1CA2CA9HDAC8
SCHEMBL1697601 0.86 DHFR (0.40) CA12CA1CA2CA9HDAC8
SCHEMBL8759193 0.86 MEN1 (0.44) CA12CA1CA2CA9HDAC8
SCHEMBL17740544 0.85 CA12 (0.38) CA12CA1CA2CA9HDAC8
SCHEMBL2353925 0.84 ALDH1A1 (0.39) CA12CA1CA2CA9HDAC8
SCHEMBL3798335 0.83 CA12 (0.62) CA12CA1CA2CA9HDAC8
SCHEMBL30083975 0.81 MCL1 (0.43) CA12CA1CA2CA9HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4356169-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2024-04-24 EP claimed
WO-2022263994-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES ALCON INC. (CH) 2022-12-22 WO claimed
EP-4356169-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2024-04-24 EP disclosed
WO-2022263994-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES ALCON INC. (CH) 2022-12-22 WO disclosed
CN-109154677-B Low viscosity agent for high refractive index polymerizable compound and polymerizable composition containing same 日产化学株式会社 2022-07-05 CN disclosed
EP-2606054-B1 FUNCTIONALIZED POLYHEDRAL OCTAVINYLSILSESQUIOXANES ADAM MICKIEWICZ UNIV (PL) 2018-10-03 EP disclosed
US-9018400-B2 Functionalized polyhedral octavinylsilsesquioxanes and a method to obtain the functionalized polyhedral octavinylsilsesquioxanes ADAM MICKIEWICZ UNIVERSITY (PL) 2015-04-28 US disclosed
WO-2015023001-A1 NOVEL ORGANOPOLYSILOXANE, SURFACE TREATMENT AGENT COMPRISING THE SAME, RESIN COMPOSITION COMPRISING THE SAME, AND GELATINOUS PRODUCT OR CURED PRODUCT THEREOF DOW CORNING TORAY CO., LTD. (JP) 2015-02-19 WO disclosed
EP-2606054-A1 FUNCTIONALIZED POLYHEDRAL OCTAVINYLSILSESQUIOXANES Adam Mickiewicz University (PL) 2013-06-26 EP disclosed
US-20130102793-A1 NEW FUNCTIONALIZED POLYHEDRAL OCTAVINYLSILSESQUIOXANES AND A METHOD TO OBTAIN THE FUNCTIONALIZED POLYHEDRAL OCTAVINYLSILSESQUIOXANES ADAM MICKIEWICZ UNIVERSITY (PL) 2013-04-25 US disclosed
CN-103052645-A Functionalized polyhedral octavinylsilsesquioxanes UNIV ADAM MICKIEWICZ 2013-04-17 CN disclosed
EP-0559108-A1 Graft copolymer, process for production thereof and resin composition containing same IDEMITSU KOSAN COMPANY LIMITED (JP) 1993-09-08 EP disclosed
EP-0511407-A1 STYRENIC COPOLYMER AND PRODUCTION THEREOF IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-11-04 EP disclosed
EP-0320538-B1 THERMOPLASTIC ELASTOMER COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1992-08-19 EP disclosed
EP-0490269-A1 Graft copolymer and process for producing the same IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-06-17 EP disclosed
US-5055519-A Oil resistance and tear strength SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1991-10-08 US disclosed
EP-0444210-A1 ARYLSTYRENE POLYMER AND COPOLYMER AND PROCESS FOR PREPARING THE SAME IDEMITSU KOSAN COMPANY LIMITED (JP) 1991-09-04 EP disclosed
EP-0344175-A1 THERMOPLASTIC ELASTOMER COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1989-12-06 EP disclosed
WO-1989005837-A1 THERMOPLASTIC ELASTOMER COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1989-06-29 WO disclosed
EP-0320538-A1 Thermoplastic elastomer compositions and process for the preparation thereof SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1989-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130102793-A1 NEW FUNCTIONALIZED POLYHEDRAL OCTAVINYLSILSESQUIOXANES AND A METHOD TO OBTAIN THE FUNCTIONALIZED POLYHEDRAL OCTAVINYLSILSESQUIOXANES YBX1, OGFRL1, SIGMAR1 CA12 2788/4885CA1 2450/4885CA2 4144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.