Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.79 |
| ▸ | MMP13 | P45452 | 14/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813091 | 0.98 | MMP1 (0.76) | MMP1MMP13SMN1; SMN2MMP9MMP2 | |
| SCHEMBL6813089 | 0.92 | MMP1 (0.67) | MMP1MMP13SMN1; SMN2MMP9MMP2 | |
| SCHEMBL6813262 | 0.92 | MMP1 (0.67) | MMP1MMP13SMN1; SMN2MMP9MMP2 | |
| SCHEMBL6693057 | 0.92 | MMP1 (0.68) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6691163 | 0.91 | MMP1 (0.65) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL3914707 | 0.90 | MMP1 (0.63) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6689128 | 0.90 | MMP1 (0.65) | MMP1MMP13SMN1; SMN2MMP9MMP2 | |
| SCHEMBL26986 | 0.88 | MMP1 (1.00) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6809653 | 0.88 | MMP1 (0.62) | MMP1MMP13SMN1; SMN2CETPLTA4H | |
| SCHEMBL6862342 | 0.87 | MMP1 (0.59) | MMP1MMP13SMN1; SMN2MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952148-B1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2004-05-12 | — | — | EP | claimed |
| US-6156798-A | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-12-05 | — | — | US | claimed |
| EP-0952148-A1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | claimed |
| JP-11322705-A | — | — | None | — | — | JP | disclosed |
| EP-0952148-B1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6156798-A | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| JP-H11322705-A | CYCLOBUTYL-ARYLOXYARYLSULFONYLAMINOHYDROXAMIC ACID DERIVATIVE | PFIZER PROD INC | 1999-11-24 | — | — | JP | disclosed |
| EP-0952148-A1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |