Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.67 |
| ▸ | MMP13 | P45452 | 16/20 | 0.52 |
| ▸ | MMP14 | P50281 | 7/20 | 0.52 |
| ▸ | MMP2 | P08253 | 5/20 | 0.52 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.52 |
| ▸ | MMP8 | P22894 | 5/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP10 | P09238 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347709 | 0.93 | MMP1 (0.56) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6870820 | 0.92 | MMP1 (0.58) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL3921083 | 0.92 | MMP1 (0.55) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6691684 | 0.92 | MMP1 (0.79) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6813091 | 0.92 | MMP1 (0.76) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6813516 | 0.91 | MMP1 (0.54) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6866226 | 0.90 | MMP1 (0.55) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6813089 | 0.90 | MMP1 (0.67) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL6870892 | 0.89 | MMP1 (0.52) | MMP1MMP13MMP14MMP2MMP3 | |
| SCHEMBL5413107 | 0.89 | MMP1 (0.68) | MMP1MMP13MMP14MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417229-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-07-09 | — | — | US | claimed |
| EP-1088550-A1 | alpha-sulfonylamino hydroxamic acid inhibitors of matrix metallo-proteinases for the treatment of peripheral or central nervous system disorders | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | claimed |
| EP-1068180-B1 | PROCESS FOR ALKYLATING HINDERED SULFONAMIDES USEFUL IN THE PRODUCTION OF MATRIX METALLOPROTENASE INHIBITORS | PFIZER PROD INC (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1415984-A1 | Aryloxyarylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1003720-B1 | ARYLOXYARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | PFIZER PROD INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-6417229-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-07-09 | — | — | US | disclosed |
| EP-0949245-B1 | Process for alkylating hindered sulfonamides | PFIZER PROD INC (US) | 2001-10-04 | — | — | EP | disclosed |
| US-6288246-B1 | REACTION OF HYDROXYLAMINE WITH ALKYLSILYL HALIDE, HYDROLYSIS WITH ACID | PFIZER INC | 2001-09-11 | — | — | US | disclosed |
| US-6214872-B1 | ANTIARTHRITIC AND ANTICARCINOGENIC AGENTS | PFIZER INC. | 2001-04-10 | — | — | US | disclosed |
| EP-1088550-A1 | alpha-sulfonylamino hydroxamic acid inhibitors of matrix metallo-proteinases for the treatment of peripheral or central nervous system disorders | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6114568-A | Process for alkylating hindered sulfonamides useful in the production of matrix metalloproteinase inhibitors | PFIZER INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-1003720-A1 | ARYLOXYARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-0949244-A2 | Process for preparing hydroxamic acids | Pfizer Products Inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| EP-0949245-A1 | Process for alkylating hindered sulfonamides | Pfizer Products Inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1999007675-A1 | ARYLOXYARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-02-18 | — | — | WO | disclosed |