Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.68 |
| ▸ | MMP13 | P45452 | 9/20 | 0.43 |
| ▸ | MMP2 | P08253 | 7/20 | 0.43 |
| ▸ | MMP9 | P14780 | 6/20 | 0.43 |
| ▸ | MMP8 | P22894 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 4/20 | 0.43 |
| ▸ | MMP14 | P50281 | 4/20 | 0.42 |
| ▸ | MMP16 | P51512 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870820 | 0.92 | MMP1 (0.58) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6691684 | 0.92 | MMP1 (0.79) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6691163 | 0.92 | MMP1 (0.65) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL3914707 | 0.91 | MMP1 (0.63) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6813091 | 0.90 | MMP1 (0.76) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6699509 | 0.89 | MMP1 (0.84) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6876444 | 0.87 | MMP1 (0.81) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL3921083 | 0.84 | MMP1 (0.55) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6813089 | 0.84 | MMP1 (0.67) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6813516 | 0.84 | MMP1 (0.54) | MMP1MMP13MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952148-B1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6156798-A | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0952148-A1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |