Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111438 | 0.81 | TSHR (0.58) | TSHRALDH1A1KDM4ESMN1; SMN2KEAP1 | |
| SCHEMBL8267288 | 0.79 | GLA (0.56) | TDP1ALDH1A1KDM4EHTR2AHTR2B | |
| SCHEMBL7106263 | 0.79 | TSHR (0.61) | TSHRALDH1A1KDM4ESMN1; SMN2KEAP1 | |
| SCHEMBL12120192 | 0.79 | TDP1 (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL20280727 | 0.78 | TSHR (0.53) | TDP1TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL501602 | 0.78 | TSHR (0.53) | TDP1TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL92600 | 0.78 | TSHR (0.53) | TDP1TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11428304 | 0.78 | TSHR (0.53) | TDP1TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4710666 | 0.78 | KDM4E (0.53) | TDP1TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10283589 | 0.78 | TSHR (0.45) | TSHRALDH1A1KDM4ESMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950657-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | LILLY CO ELI (US) | 2004-07-14 | — | — | EP | claimed |
| US-5698569-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-12-16 | — | — | US | disclosed |