⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661274 | 0.83 | — | — | |
| SCHEMBL9061860 | 0.75 | LMNA (0.39) | — | |
| SCHEMBL7532952 | 0.67 | — | — | |
| SCHEMBL6267455 | 0.67 | — | — | |
| SCHEMBL23418989 | 0.64 | NOS2 (0.32) | — | |
| SCHEMBL14000036 | 0.64 | — | — | |
| SCHEMBL19047399 | 0.62 | — | — | |
| SCHEMBL2959600 | 0.61 | — | — | |
| SCHEMBL15272133 | 0.61 | — | — | |
| SCHEMBL11880935 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261657-B1 | POLY(3-CYCLOPROPYL-3-HYDROXYPROPIONATE) AND PROCESSES FOR ITS PREPARATION AND DERIVATIVES THEREOF | EASTMAN CHEM CO (US) | 2004-11-10 | — | — | EP | disclosed |
| US-20040210030-A1 | Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof | HUBBS JOHN CLARK (US) | 2004-10-21 | — | — | US | disclosed |
| US-6710206-B2 | HEATING TO DEHYDROGENATE AND FORM 3-CYCLOPROPYLACRYLIC ACID; VINYLCYCLOPROPANE AND CYCLOPROPYLACETYLENE PREPARATION | EASTMAN CHEMICAL COMPANY | 2004-03-23 | — | — | US | disclosed |
| US-20030212294-A1 | Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof | HUBBS JOHN CLARK (US) | 2003-11-13 | — | — | US | disclosed |
| US-20030208092-A1 | Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof | HUBBS JOHN CLARK (US) | 2003-11-06 | — | — | US | disclosed |
| US-6610878-B1 | Catalytic reaction of cyclopropanecarboxaldehyde and ketene; intermediates to vinylcyclopropane, cyclopropylacetylene and cyclopropylacrylic; inexpensive | EASTMAN CHEMICAL COMPANY | 2003-08-26 | — | — | US | disclosed |
| EP-1261657-A2 | POLY(3-CYCLOPROPYL-3-HYDROXYPROPIONATE) AND PROCESSES FOR ITS PREPARATION AND DERIVATIVES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6297410-B1 | 1-BROMO-2-CYCLOPROPYLETHYLENE WHICH MAY BE EFFICIENTLY DEHYDROHALOGENATED TO YIELD CYCLOPROPYLACETYLENE, THE CHEMICAL INTERMEDIATE FOR AN HIV REVERSE TRANSCRIPTASE INHIBITOR | DUPONT PHARMACEUTICALS COMPANY | 2001-10-02 | — | — | US | disclosed |
| WO-2000068290-A2 | POLY(3-CYCLOPROPYL-3-HYDROXYPROPIONATE) AND PROCESSES FOR ITS PREPARATION AND DERIVATIVES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2000-11-16 | — | — | WO | disclosed |
| EP-1000001-A1 | A PROCESS FOR THE PREPARATION OF CYCLOPROPYLACETYLENE | Dupont Pharmaceuticals Company (US) | 2000-05-17 | — | — | EP | disclosed |
| US-6049019-A | Process for the preparation of cyclopropylacetylene | DUPONT PHARMACEUTICALS (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1999006341-A1 | A PROCESS FOR THE PREPARATION OF CYCLOPROPYLACETYLENE | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |
| EP-0002263-B1 | 3-TRIFLUOROMETHYLSULFINYL ANALOGS OF CYPROHEPTADINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF | MERCK & CO. INC. (US) | 1981-10-28 | — | — | EP | disclosed |
| EP-0002263-A1 | 3-Trifluoromethylsulfinyl analogs of cyproheptadine, process for their preparation and pharmaceutical composition thereof | MERCK & CO. INC. (US) | 1979-06-13 | — | — | EP | disclosed |
| US-4132796-A | Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine | MERCK & CO., INC. (US) | 1979-01-02 | — | — | US | disclosed |
| US-4031222-A | ANTIEXTRAPYRAMIDAL, ANTIPSYCHOTIC, ENANTIOMERS, TRANQUILIZERS, ANTICHOLINERGIC | MERCK & CO., INC. (US) | 1977-06-21 | — | — | US | disclosed |