Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 9/20 | 0.51 |
| ▸ | MTTP | P55157 | 13/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692221 | 0.84 | APOB (0.53) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL31393757 | 0.80 | CHRNB2 (0.71) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6673930 | 0.77 | MTTP (0.51) | APOBMTTPGAAKDM4ESMN1; SMN2 | |
| SCHEMBL6675345 | 0.75 | MTTP (0.49) | APOBMTTPGAAKDM4ESMN1; SMN2 | |
| SCHEMBL3726223 | 0.75 | NPC1 (0.61) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6794747 | 0.74 | PTGS1 (0.60) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6799012 | 0.74 | APOB (0.66) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7605815 | 0.74 | APOB (0.63) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7607266 | 0.73 | APOB (0.65) | APOBMTTPCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6791178 | 0.73 | PTGS1 (0.67) | APOBMTTPCHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003004020-A1 | HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-16 | — | — | WO | disclosed |