Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948723 | 0.99 | THRA (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL9536383 | 0.90 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL21596582 | 0.84 | HDAC1 (0.45) | HDAC1HDAC3HDAC2THRACETP | |
| SCHEMBL21596592 | 0.84 | HDAC1 (0.45) | HDAC1HDAC3HDAC2THRACETP | |
| SCHEMBL21596589 | 0.84 | HDAC1 (0.45) | HDAC1HDAC3HDAC2THRACETP | |
| SCHEMBL11155511 | 0.84 | TTR (0.44) | ALDH1A1NPC1RAB9APTPN1THRA | |
| SCHEMBL4406264 | 0.83 | THRA (0.48) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL9609686 | 0.82 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL524255 | 0.82 | CES2 (0.50) | ALDH1A1CES2CES1LMNA | |
| SCHEMBL7947562 | 0.81 | KDM4E (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973516-B1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | UNIV STRATHCLYDE (GB) | 2004-06-23 | — | — | EP | disclosed |
| EP-0973516-A1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | University of Strathclyde (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998044920-A1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | UNIVERSITY OF STRATHCLYDE (GB) | 1998-10-15 | — | — | WO | disclosed |
| EP-0532531-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |