Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315018 | 0.90 | KMT2A (0.36) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6685583 | 0.83 | MEN1 (0.41) | HTTAPOBEC3AAPOBEC3GMEN1KMT2A | |
| SCHEMBL6321113 | 0.82 | GAA (0.40) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL6318228 | 0.80 | LMNA (0.34) | LMNASMN1; SMN2GAA | |
| SCHEMBL6318232 | 0.80 | LMNA (0.40) | KMT2AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6692830 | 0.79 | LMNA (0.35) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6321009 | 0.79 | LMNA (0.40) | KMT2AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6317350 | 0.78 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6315810 | 0.78 | KMT2A (0.37) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6323871 | 0.78 | KMT2A (0.37) | MEN1KMT2AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002072549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-09-19 | — | — | WO | disclosed |