Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316780 | 0.90 | SIGMAR1 (0.41) | MEN1KMT2AMAPTALDH1A1MDM2 | |
| SCHEMBL6315618 | 0.83 | ALOX5 (0.39) | MEN1KMT2AMAPTALDH1A1MDM2 | |
| SCHEMBL6692790 | 0.83 | HTT (0.36) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL6321200 | 0.82 | SIGMAR1 (0.44) | MAPTALDH1A1MDM2LMNASMN1; SMN2 | |
| SCHEMBL6317151 | 0.80 | KMT2A (0.36) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL6316011 | 0.80 | SLC6A3 (0.40) | MDM2SLC6A3 | |
| SCHEMBL6316297 | 0.80 | MAPK14 (0.40) | MEN1KMT2AMAPTALDH1A1MDM2 | |
| SCHEMBL6316014 | 0.80 | SIGMAR1 (0.44) | LMNASMN1; SMN2SIGMAR1 | |
| SCHEMBL6316794 | 0.79 | LMNA (0.39) | MEN1KMT2AMAPTALDH1A1MDM2 | |
| SCHEMBL6316049 | 0.79 | SIGMAR1 (0.45) | LMNASMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002072549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-09-19 | — | — | WO | disclosed |