⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9661510 | 1.00 | — | — | |
| SCHEMBL16611889 | 0.80 | — | — | |
| SCHEMBL9184329 | 0.79 | — | — | |
| SCHEMBL14314366 | 0.74 | — | — | |
| SCHEMBL5768296 | 0.74 | — | — | |
| SCHEMBL4559467 | 0.74 | — | — | |
| SCHEMBL6976367 | 0.72 | — | — | |
| SCHEMBL18566773 | 0.72 | — | — | |
| SCHEMBL9035200 | 0.72 | — | — | |
| SCHEMBL6976364 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1045389-A | — | — | None | — | — | JP | disclosed |
| JP-58222088-A | — | — | None | — | — | JP | disclosed |
| JP-56135464-A | — | — | None | — | — | JP | disclosed |
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-116829151-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2004089362-A1 | 2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS | NOVO NORDISK A/S (DK) | 2004-10-21 | — | — | WO | disclosed |
| JP-S6445389-A | 3-AMINO-4-(DIHYDROXYPHOSPHINYL)BUTANOIC ACID AND PRODUCTION THEREOF | UNIV SHIZUOKA | 1989-02-17 | — | — | JP | disclosed |
| US-4739048-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1988-04-19 | — | — | US | disclosed |
| US-4736025-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1988-04-05 | — | — | US | disclosed |
| JP-S56135464-A | PREPARATION OF 4-IODOMETHYL-2-AZETIDINONE | SANKYO CO LTD | 1981-10-22 | — | — | JP | disclosed |
| EP-0037081-A1 | Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates | MERCK & CO. INC. (US) | 1981-10-07 | — | — | EP | disclosed |
| EP-0037082-A1 | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals | MERCK & CO. INC. (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4290947-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4275207-A | Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor | MERCK & CO., INC. (US) | 1981-06-23 | — | — | US | disclosed |
| EP-0026816-A1 | Intermediates for the preparation of thienamycin and process for preparing intermediates | MERCK & CO. INC. (US) | 1981-04-15 | — | — | EP | disclosed |
| EP-0007973-A1 | Process for the preparation of thienamycin and intermediates | MERCK & CO. INC. (US) | 1980-02-20 | — | — | EP | disclosed |
| US-4174316-A | 4-Iodomethylazetidin-2-one | MERCK & CO., INC. (US) | 1979-11-13 | — | — | US | disclosed |
| US-4174316-A | 4-Iodomethylazetidin-2-one | MERCK & CO., INC. (US) | 1979-11-13 | — | — | US | disclosed |
| US-4174316-A | 4-Iodomethylazetidin-2-one | MERCK & CO., INC. (US) | 1979-11-13 | — | — | US | disclosed |