Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | F12 | P00748 | 6/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973253 | 0.81 | CTSS (0.42) | GPR119EPHX2CCNT1CDK9CTSS | |
| SCHEMBL6686186 | 0.74 | CCNT1 (0.36) | EPHX2CCNT1CDK9RORC | |
| SCHEMBL6694455 | 0.74 | CTSS (0.39) | GPR119EPHX2CCNT1CDK9PCSK9 | |
| SCHEMBL6690191 | 0.73 | F12 (0.40) | F12F2 | |
| SCHEMBL2258801 | 0.65 | KMT2A (0.39) | HTR1AHTR1DHTR1FF12 | |
| SCHEMBL6687211 | 0.64 | F12 (0.38) | HTR1AHTR1DHTR1FF12F2 | |
| SCHEMBL29135644 | 0.63 | MKNK2 (0.44) | GPR119AAK1 | |
| SCHEMBL6689109 | 0.63 | MEN1 (0.41) | CTSSCTSKAAK1 | |
| SCHEMBL2375918 | 0.62 | MKNK2 (0.45) | EPHX2CTSSCTSKAAK1 | |
| SCHEMBL5484730 | 0.62 | HTR1A (0.44) | GPR119CCNT1CDK9HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004112709-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-12-29 | — | — | WO | disclosed |