Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493508 | 0.80 | TACR2 (0.38) | MEN1KMT2AGRM5 | |
| SCHEMBL6691584 | 0.78 | GRM5 (0.38) | MEN1KMT2AGRM5 | |
| SCHEMBL6690790 | 0.74 | SYK (0.34) | CTSSPPARASYKKLK7KLK5 | |
| SCHEMBL6690009 | 0.72 | CTSS (0.46) | CTSSPPARACTSKCTSLRAB9A | |
| SCHEMBL22018391 | 0.71 | PPARA (0.57) | CTSSPPARASYKPPARGKLK7 | |
| SCHEMBL23574227 | 0.71 | PPARA (0.59) | CTSSPPARASYKPPARGKLK7 | |
| SCHEMBL6689978 | 0.71 | SIGMAR1 (0.33) | CTSSPPARASYKCTSLRAB9A | |
| SCHEMBL6694455 | 0.70 | CTSS (0.39) | CTSSGPR119CTSKCTSLEPHX2 | |
| SCHEMBL397978 | 0.70 | PPARA (0.58) | CTSSPPARASYKPPARGKLK7 | |
| SCHEMBL29295304 | 0.70 | PPARA (0.58) | CTSSPPARASYKPPARGKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658274-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-11-12 | — | — | EP | disclosed |
| EP-1658274-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005018568-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-03-03 | — | — | WO | disclosed |
| WO-2004112709-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-12-29 | — | — | WO | disclosed |