Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667217 | 0.87 | LMNA (0.65) | LMNAL3MBTL1MAPTFFAR4FFAR1 | |
| SCHEMBL8984884 | 0.85 | LMNA (0.63) | LMNAL3MBTL1FFAR4FFAR1PPARG | |
| SCHEMBL3693650 | 0.83 | LMNA (0.60) | LMNAL3MBTL1KDM4EALDH1A1POLB | |
| SCHEMBL7398838 | 0.82 | GAA (0.59) | LMNAL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL9679355 | 0.80 | RXRA (0.63) | LMNAL3MBTL1FFAR4FFAR1PPARG | |
| SCHEMBL3667760 | 0.79 | LMNA (0.59) | LMNAL3MBTL1FFAR4FFAR1PPARG | |
| SCHEMBL11790621 | 0.79 | MAPT (0.62) | USP2KDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL8984888 | 0.77 | LMNA (0.52) | LMNAL3MBTL1MEN1KMT2AFFAR4 | |
| SCHEMBL31254179 | 0.77 | PTGDR2 (0.58) | LMNAL3MBTL1FFAR4FFAR1S1PR1 | |
| SCHEMBL3443299 | 0.76 | CYP1A2 (0.61) | USP2KDM4EMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-1004580-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004581-A2 | Process for the preparation of thalidomide | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004572-A2 | Amines as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5605914-A | INHIBITORS OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |