Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.49 |
| ▸ | TACR1 | P25103 | 7/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TACR3 | P29371 | 6/20 | 0.45 |
| ▸ | TACR2 | P21452 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296155 | 0.86 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| SCHEMBL7010561 | 0.77 | TACR2 (0.61) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| SCHEMBL7305744 | 0.77 | TACR3 (0.72) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| Hydrochloric Acid SCHEMBL6543413 | 0.77 | TACR2 (0.60) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| SCHEMBL6693662 | 0.76 | TACR1 (0.74) | TACR1CYP2D6TACR3TACR2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7751688 | 0.76 | TACR3 (0.71) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| SCHEMBL7305689 | 0.75 | TACR2 (0.51) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| SCHEMBL6468201 | 0.75 | TACR1 (0.75) | TACR1CYP2D6TACR3TACR2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8012872 | 0.75 | TACR2 (0.50) | SLC6A2SLC6A4SLC6A3TACR1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8185846 | 0.74 | TACR1 (0.53) | TACR1CYP2D6TACR3TACR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006135-A1 | Combination treatment for depression and anxiety | PFIZER INC. | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006135-A1 | Combination treatment for depression and anxiety | TACR1, NPSR1, HTR3A | SLC6A2 41/4885SLC6A4 54/4885SLC6A3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.