SCHEMBL6693668

SCHEMBL6693668

COc1ccc2nc(SSc3nc4ccc(OC)cc4s3)sc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 1/20 1.00
CYP1A2 P05177 3/20 0.63
CYP2C19 P33261 3/20 0.63
CYP3A4 P08684 2/20 0.63
MAPT P10636 5/20 0.56
LMNA P02545 1/20 0.56
MAPK1 P28482 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
RAB9A P51151 5/20 0.55
NPC1 O15118 4/20 0.55
SMN1; SMN2 Q16637 4/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
TSHR P16473 1/20 0.55
APP P05067 4/20 0.54
HTT P42858 2/20 0.52
DYRK1A Q13627 1/20 0.52
NFKB1 P19838 1/20 0.52
NFKB2 Q00653 1/20 0.52
RELA Q04206 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6902779 0.90 PDK1 (0.81) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL31291763 0.88 PDK1 (0.79) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL6690265 0.86 PDK1 (0.76) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL17950538 0.83 PDK1 (0.70) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL30253184 0.83 PDK1 (0.70) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL31294142 0.83 PDK1 (0.70) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL28589570 0.83 PDK1 (0.70) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL6689290 0.82 PDK1 (0.69) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL9389916 0.81 PDK1 (0.67) PDK1CYP1A2CYP2C19CYP3A4MAPT
SCHEMBL31038134 0.81 PDK1 (0.67) PDK1CYP1A2CYP2C19CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US claimed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP claimed
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed
US-4332884-A USING A DIOXIME CHELATING AGENT RICOH CO., LTD. (JP) 1982-06-01 US disclosed
US-4306014-A AMMONIA OR AMINES SUPPRESS THE COLOR-FORMING REACTION SYSTEM RICOH CO., LTD. (JP) 1981-12-15 US disclosed