Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669655 | 1.00 | KCNH2 (0.38) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL14974361 | 1.00 | KCNH2 (0.38) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL14984858 | 1.00 | KCNH2 (0.38) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL14987837 | 0.91 | HTR2A (0.37) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL17750791 | 0.85 | CYP2D6 (0.40) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL22454446 | 0.85 | CYP2D6 (0.40) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL669770 | 0.85 | LMNA (0.39) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL669526 | 0.85 | LMNA (0.39) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL14974352 | 0.85 | LMNA (0.39) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 | |
| SCHEMBL14987836 | 0.82 | KCNH2 (0.41) | KCNH2OPRM1OPRD1HTR2AMRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606030-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | Indoco Remedies Limited (IN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012023147-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2012-02-23 | — | — | WO | disclosed |