Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14974352 | 1.00 | LMNA (0.39) | LMNACYP3A4CYP2D6POLBMAPT | |
| SCHEMBL669526 | 1.00 | LMNA (0.39) | LMNACYP3A4CYP2D6POLBMAPT | |
| SCHEMBL669655 | 0.85 | KCNH2 (0.38) | LMNACYP3A4CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL14984858 | 0.85 | KCNH2 (0.38) | LMNACYP3A4CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL669373 | 0.85 | KCNH2 (0.38) | LMNACYP3A4CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL14974361 | 0.85 | KCNH2 (0.38) | LMNACYP3A4CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL669527 | 0.82 | HTR6 (0.38) | POLBMAPTTP53ALDH1A1HTR6 | |
| SCHEMBL22454446 | 0.80 | CYP2D6 (0.40) | LMNACYP3A4CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL17750791 | 0.80 | CYP2D6 (0.40) | LMNACYP3A4CYP2D6ALDH1A1KCNH2 | |
| SCHEMBL14987836 | 0.77 | KCNH2 (0.41) | LMNACYP3A4CYP2D6POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606030-B1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LTD (IN) | 2016-05-18 | — | — | EP | claimed |
| US-8853456-B2 | Process for the preparation of tapentadol | INDOCO REMEDIES LIMITED (US) | 2014-10-07 | — | — | US | claimed |
| EP-2606030-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | Indoco Remedies Limited (IN) | 2013-06-26 | — | — | EP | claimed |
| US-20130137890-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2013-05-30 | — | — | US | claimed |
| WO-2012023147-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2012-02-23 | — | — | WO | claimed |
| EP-2606030-B1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LTD (IN) | 2016-05-18 | — | — | EP | disclosed |
| US-8853456-B2 | Process for the preparation of tapentadol | INDOCO REMEDIES LIMITED (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2606030-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | Indoco Remedies Limited (IN) | 2013-06-26 | — | — | EP | disclosed |
| US-20130137890-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2013-05-30 | — | — | US | disclosed |
| WO-2012023147-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137890-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | OPRD1, OPRM1, OPRK1 | LMNA 2991/4885CYP3A4 28/4885CYP2D6 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.