SCHEMBL6693785

SCHEMBL6693785

CCOc1ccc2nc(SNC(C)(C)C)sc2c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 4/20 0.62
MAPT P10636 10/20 0.60
LMNA P02545 6/20 0.60
L3MBTL1 Q9Y468 4/20 0.60
MAPK1 P28482 1/20 0.60
TDP1 Q9NUW8 3/20 0.59
HTT P42858 2/20 0.59
ALDH1A1 P00352 5/20 0.56
KMT2A Q03164 5/20 0.56
HSD17B10 Q99714 3/20 0.56
CYP3A4 P08684 2/20 0.56
TP53 P04637 1/20 0.56
TSHR P16473 1/20 0.56
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
ALOX5 P09917 1/20 0.53
GAA P10253 1/20 0.53
SMN1; SMN2 Q16637 5/20 0.51
HPGD P15428 4/20 0.51
MEN1 O00255 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691037 0.90 PPARA (0.51) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6691229 0.90 PPARA (0.50) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6692270 0.85 PDK1 (0.67) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6693725 0.84 MAPT (0.61) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL8358167 0.83 PPARA (0.73) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6689290 0.82 PDK1 (0.69) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6902202 0.82 MAPT (0.66) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6665955 0.81 MAPT (0.64) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL8357768 0.81 MAPT (0.65) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6690919 0.80 PPARA (0.43) PPARAMAPTLMNAL3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US claimed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP claimed
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed