SCHEMBL6691037

SCHEMBL6691037

CCCCOc1ccc2nc(SNC(C)(C)C)sc2c1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 5/20 0.51
MAPT P10636 4/20 0.49
LMNA P02545 4/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
MAPK1 P28482 1/20 0.49
HTT P42858 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
PDK1 Q15118 1/20 0.46
ALDH1A1 P00352 1/20 0.44
TP53 P04637 1/20 0.44
CYP3A4 P08684 1/20 0.44
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KMT2A Q03164 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
ALOX5 P09917 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6690919 0.90 PPARA (0.43) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6693785 0.90 PPARA (0.62) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6688601 0.85 PPARA (0.50) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6692270 0.83 PDK1 (0.67) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6691987 0.83 PDK1 (0.66) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6900878 0.83 PDK1 (0.54) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6691229 0.80 PPARA (0.50) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6690928 0.78 ALDH1A1 (0.57) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6694325 0.75 PPARA (0.42) PPARAMAPTLMNAL3MBTL1MAPK1
SCHEMBL6697899 0.75 HSP90AA1 (0.42) ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed