Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MPI | P34949 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471667 | 0.87 | MAPT (0.63) | ALDH1A1MAPTPOLBL3MBTL1MAPK1 | |
| SCHEMBL9439971 | 0.76 | HSD17B3 (0.61) | ALDH1A1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL9439906 | 0.74 | ALDH1A1 (0.63) | ALDH1A1MAPTMAPK1KMT2AKDM4E | |
| SCHEMBL9439988 | 0.72 | GSK3B (0.62) | ALDH1A1POLBL3MBTL1MAPK1TDP1 | |
| SCHEMBL4489396 | 0.72 | NAMPT (0.54) | ALDH1A1MAPTPOLBL3MBTL1MAPK1 | |
| SCHEMBL1304544 | 0.71 | MAPT (0.68) | ALDH1A1MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL1304505 | 0.71 | RAB9A (0.64) | ALDH1A1MAPTPOLBL3MBTL1MAPK1 | |
| SCHEMBL522192 | 0.70 | ALDH1A1 (0.64) | ALDH1A1MAPTL3MBTL1TDP1KMT2A | |
| SCHEMBL11401029 | 0.70 | POLB (0.73) | ALDH1A1MAPTPOLBL3MBTL1KMT2A | |
| SCHEMBL6632472 | 0.69 | POLB (0.79) | ALDH1A1MAPTPOLBL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | Abbott Laboratories (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080625-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-10-02 | — | — | WO | disclosed |