Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.48 |
| ▸ | F10 | P00742 | 8/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693347 | 0.91 | PLA2G2A (0.51) | PLA2G2AF10F2MAPK8ADRA1D | |
| SCHEMBL30410173 | 0.86 | PLA2G2A (0.40) | PLA2G2ARPS6KB1MAPK8ADRA1D | |
| SCHEMBL29029773 | 0.86 | PLA2G2A (0.40) | PLA2G2ARPS6KB1MAPK8ADRA1D | |
| SCHEMBL6691732 | 0.86 | ADRA1D (0.44) | PLA2G2AF10F2MAPK8ADRA1D | |
| SCHEMBL6693555 | 0.85 | GAA (0.45) | PLA2G2AF10F2KDM4EALDH1A1 | |
| SCHEMBL6690357 | 0.84 | PLA2G2A (0.51) | PLA2G2AALDH1A1 | |
| SCHEMBL5212989 | 0.84 | PLA2G2A (0.58) | PLA2G2AF10ADRA1DKDM4EALDH1A1 | |
| SCHEMBL7467933 | 0.82 | RPS6KB1 (0.36) | PLA2G2AF10F2RPS6KB1MAPK8 | |
| SCHEMBL6690183 | 0.81 | PLA2G2A (0.62) | PLA2G2AF10MAPK8ADRA1DKDM4E | |
| SCHEMBL6691129 | 0.81 | F10 (0.46) | PLA2G2AF10F2RPS6KB1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |