Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050803 | 0.92 | ADRA1D (0.44) | RPS6KB1MAPK8PLA2G2AADRA1DF10 | |
| SCHEMBL27508047 | 0.89 | P2RX4 (0.42) | PLA2G2APARP1MEN1ALDH1A1KMT2A | |
| SCHEMBL27505227 | 0.89 | RPS6KB1 (0.35) | RPS6KB1MAPK8PLA2G2AADRA1DF10 | |
| SCHEMBL27507597 | 0.89 | MEN1 (0.39) | PLA2G2AF10PARP1MEN1ALDH1A1 | |
| SCHEMBL27563118 | 0.86 | RPS6KB1 (0.39) | RPS6KB1PLA2G2AADRA1DF10F2 | |
| SCHEMBL27506446 | 0.86 | PLA2G2A (0.40) | MAPK8PLA2G2AADRA1DF10F2 | |
| SCHEMBL27530595 | 0.86 | GPR52 (0.37) | RPS6KB1MAPK8PLA2G2AF10PARP1 | |
| SCHEMBL27531172 | 0.86 | RPS6KB1 (0.34) | RPS6KB1MAPK8PLA2G2AADRA1DF10 | |
| SCHEMBL6612458 | 0.85 | PLA2G2A (0.44) | PLA2G2AADRA1DPARP1 | |
| SCHEMBL7946053 | 0.85 | SIRT2 (0.39) | RPS6KB1MAPK8ADRA1DPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259260-A1 | COMBINATION THERAPY FOR THE TREATMENT OF INFLAMMATORY AND RESPIRATORY DISEASES | ELI LILLY AND COMPANY (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001055108-A2 | USE OF SPL A2 INHIBITORS FOR THE TREATMENT OF INFLAMMATION | ELI LILLY AND COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |
| WO-2001049323-A1 | COMBINATION THERAPY FOR THE TREATMENT OF INFLAMMATORY AND RESPIRATORY DISEASES | ELI LILLY AND COMPANY (US) | 2001-07-12 | — | — | WO | disclosed |
| CN-1240210-A | Substituted tricyclic compound | LILLY CO ELI (US) | 2000-01-05 | — | — | CN | disclosed |