Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.84 |
| ▸ | MEN1 | O00255 | 8/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.84 |
| ▸ | LMNA | P02545 | 6/20 | 0.84 |
| ▸ | HTT | P42858 | 5/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 2/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | USP2 | O75604 | 2/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691573 | 0.77 | LMNA (0.66) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL12979896 | 0.76 | KDM4E (0.76) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL12980595 | 0.76 | KDM4E (0.72) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL665000 | 0.75 | TP53 (0.81) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL12136724 | 0.75 | NFKB1 (0.67) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6687323 | 0.74 | MAPT (0.81) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4920382 | 0.74 | MAPT (0.65) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL5713545 | 0.73 | MAPT (0.67) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6684638 | 0.73 | MAPT (0.84) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL19680027 | 0.72 | HSD17B10 (0.61) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078115-A2 | BENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF ROTAVIRUS INFECTIONS AND ASSOCIATED DISEASES | VIROPHARMA, INCORPORATED (US) | 2004-09-16 | — | — | WO | disclosed |